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- Title
A diplotype in the lymphotoxin alpha gene is associated with differential expression of LTA mRNA induced by Gram-positive and Gram-negative bacteria.
- Authors
Temple, S. E. L.; Almeida, C. M.; Cheong, K. Y.; Wunderink, R. G.; Waterer, G. W.
- Abstract
We sequenced the lymphotoxin alpha (LTA) promoter and identified LTA10G>A in strong linkage with LTA252G>A and LTA723C>A. Stimulated cells from LTA723AA: LTA252GG:LTA10AA individuals had significantly higher LTA mRNA levels than LTA723CC:LTA252AA:LTA10GG and LTA723AA:LTA252AG:LTA10GA individuals, suggesting that this diplotype may contain a functional polymorphism explaining the observed disease associations with LTA252G>A.
- Subjects
NUCLEOTIDE sequence; TUMOR necrosis factors; CYTOKINES; PROMOTERS (Genetics); MESSENGER RNA; GRAM-positive bacteria; GENETIC polymorphisms
- Publication
International Journal of Immunogenetics, 2007, Vol 34, Issue 3, p157
- ISSN
1744-3121
- Publication type
Article
- DOI
10.1111/j.1744-313X.2007.00674.x