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- Title
Normalization of blood glucose in pregnant diabetics with the maximal tolerated dose (M.T.D.) of insulin.
- Authors
Roversi, G. D.; Gargiulo, M.; Nicolini, U.; Pedretti, E.; Ferrazzi, E.; Gruft, L.
- Abstract
Between 1970 and 1975 a 24-hour blood glucose check on hospitalized pregnant diabetics (including controls at fasting and five samples of capulary blood at 4-hour intervals) was routinely performed on a given day of every week. Time intervals of blood collections after meals were 4 hours or more in five samples and P/2 hours in one sample (8 p.m.). Insulin was administered to the maximum tolerated dose (M.T.D.) both to pregnant women with latent and to those with clinical diabetes [4, 5, 6, 7, 8,10]. The blood glucose data of cases coverning the complete sei of samples both before starting treatment (no insulin therapy given to patients with latent or chemical diabetes and therapy according to traditional criteria given to patients with clinical diabetes) and after reaching the M.T.D. of insulin (161 cases) were compared with data from 24-hour blood glucose checks on 69 non-diabetic pregnant women (control group). Before starting the treatment the average blood glucose values at fasting and over the 24-hour period were higher in each group of pregnant diabetics (latent diabetes: 95 cases; clinical diabetes: 66 cases; without vascular complications: 36 cases; with vascular complications: 30 cases) than in the control group. Differences vis-a-vis the control group were greater in patients with clinical than in those with latent diabetes, and in patients with vascular complications than in those without. All differences were statistically significant (Tabs. I, II; Figs. 2, 3). Individual blood glucose values in patients with clinical diabetes were widely distributed around their mean values (Figs. 4, 5). At the M.T.D. of insulin, the mean values of diabetics and control groups were almost the same. There was no statistical difference between pregnant diabetics (except in patients with latent diabetes) and the control group (Tabs. I, II; Figs. 2, 3). Individual blood glucose values were distributed in a narrow range (Figs. 4, 5). The normalization of blood glucose was not the original purpose of our treatment, but the treatment did result in normalization. This positive result is in agreement with the positive perinatal outcome of the cases studied [l, 5, 6, 7, 8, 10]. These results confirm our confidence in the particular method of insulin therapy that we use.
- Publication
Journal of Perinatal Medicine, 1980, Vol 8, Issue 4, p195
- ISSN
0300-5577
- Publication type
Article