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- Title
Immunosuppression by T regulatory cells in cows infected with Staphylococcal superantigen.
- Authors
Byoung Sun Chang; Bohach, Gregory A.; Sang-Un Lee; Davis, William C.; Fox, Lawrence K.; Ferens, Witold A.; Keun Seok Seo; Hye Cheong Koo; Nam Hoon Kwon; Yong Ho Park
- Abstract
Our recent study has provided that the in vitro SEC-induced proliferation of bovine T cells is preceded by a period of a non-proliferative immunoregulation of T cells that may be associated with cytokine production regulated by type 1 or type 2 T cells. Inversion of CD4+:CD8+ T cell ratio and induction of CD8+ T cells with immunoregulatory activity could increase the probability of intracellular survival of Staphylococcus aureus (S. aureus). The increase of activated CD8+ (ACT2+ BoCD8+) T cells in cows with mastitis caused by S. aureus may be associated with immune-regulatory function in the bovine mammary gland. The difference and similarity between bovine activated CD8+ T cells (CD8+CD26+) and well-established human CD4+CD25+ T regulatory (Tr) cells may help to reveal their unique immune regulatory system in the host infected with S. aureus.
- Subjects
IMMUNOSUPPRESSION; T cells; LYMPHOCYTES; CELLULAR immunity; CATTLE diseases; MAMMARY glands
- Publication
Journal of Veterinary Science, 2005, Vol 6, Issue 3, p247
- ISSN
1229-845X
- Publication type
Article
- DOI
10.4142/jvs.2005.6.3.247