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- Title
Rhodium(I)-Catalyzed Arylation of β-Chloro Ketones and Related Derivatives through Domino Dehydrochlorination/ Conjugate Addition.
- Authors
Jiang, Quanbin; Guo, Tenglong; Wang, Qingfu; Wu, Ping; Yu, Zhengkun
- Abstract
Highly efficient arylations of β-chloro ketones and their ester and amide derivatives were achieved by means of domino dehydrochlorination/Rh(I)-catalyzed conjugate addition. In situ generated vinyl ketones and their analogues were identified as the reaction intermediates. The present synthetic protocol provides a concise route to (chiral) β-aryl ketones, esters, and amides.
- Subjects
RHODIUM; KETONES; CONJUGATE addition reactions; AMIDE derivatives; ALKYL chlorides; CARBON-carbon bonds
- Publication
Advanced Synthesis & Catalysis, 2013, Vol 355, Issue 9, p1874
- ISSN
1615-4150
- Publication type
Article
- DOI
10.1002/adsc.201200821