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- Title
Phosphorus-nitrogen compounds.
- Authors
Akbaş, Hüseyin; Okumuş, Aytuğ; Karadağ, Ahmet; Kılıç, Zeynel; Hökelek, Tuncer; Yasemin Koç, L.; Açık, Leyla; Aydın, Betül; Türk, Mustafa
- Abstract
The salicylic acid salts of fully substituted mono(4-fluorobenzyl)spirocyclotriphosphazenes ( 10- 15) were prepared. The structures of these phosphazenium salts ( 10a- 15a) were determined by elemental analyses, FTIR and H, C{H}, P{H} NMR techniques. The crystal structure of 14a was verified by X-ray diffraction analysis. The thermal properties of the salts were investigated using TG/DTA and DSC instruments. The results obtained from DSC indicated that the melting temperatures and latent heats of the compounds were in the ranges of 107.76-143.04 °C and 41.64-69.73 J g, respectively. The thermal stabilities of the phosphazenium salts ( 10a- 15a) are found to be different, but they have a similar decomposition mechanism. The compounds 14a and 15a exhibit noticeable cytotoxic activity against DLD-1 cancer cells, and they seem to be good candidates for being anticancer agents. All of the compounds have an antimicrobial effect on bacterial and yeast strains within the ranges of 312-625 µM (bacterial strains) and 19.5-312 µM (yeast strains). It is found that compounds 13a- 15a were most effective against yeast strains. Moreover, interactions between the salts and pBR322 plasmid DNA show that 14a and 15a cleave the DNA and decrease the intensity of form I. BamHI and HindIII digestion results demonstrate that the compounds are not bound with G/G and A/A nucleotides, respectively.
- Subjects
PHOSPHORUS compounds; SALICYLIC acid; SUBSTITUTION reactions; FOURIER transform infrared spectroscopy; X-ray diffraction; CRYSTAL structure
- Publication
Journal of Thermal Analysis & Calorimetry, 2016, Vol 123, Issue 2, p1627
- ISSN
1388-6150
- Publication type
Article
- DOI
10.1007/s10973-015-5001-6