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- Title
Thermoanalytical studies on complexes of clotrimazole with cyclodextrins.
- Authors
Taneri, F.; Güneri, T.; Aigner, Z.; Berkesi, O.; Kata, M.
- Abstract
γ-Cyclodextrin and dirnethyl-β-cyclodextrin were used as solubilizing agents for a very poorly water-soluble drug, an imidazole derivative antifungal agent, clotrimazole; with the aim of improving the physicochemical properties of the drug. Solid products were prepared by physical mixing, kneading, precipitation and spray-drying methods in 1:1 and 1:2 drug:cyclodextrin molar ratios. Drug interactions were studied by thermoanalytical methods such as DSC, DTA, TG and DTG, X-ray diffractornetry and Fourier transformation-infrared spectroscopy. The results demonstrated the formation of inclusion complexes in some products.
- Subjects
CYCLODEXTRINS; ANTIFUNGAL agents; SPECTRUM analysis; THERMAL analysis; CALORIMETRY
- Publication
Journal of Thermal Analysis & Calorimetry, 2004, Vol 76, Issue 2, p471
- ISSN
1388-6150
- Publication type
Article