We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The role of single-fraction stereotactic radiosurgery for atypical meningiomas (WHO grade II): treatment results based on a 25-year experience.
- Authors
Hasegawa, Hirotaka; Vakharia, Kunal; Link, Michael J.; Stafford, Scott L.; Brown, Paul D.; Parney, Ian F.; Burns, Terry C.; Yan, Elizabeth S.; Mahajan, Anita; Laack, Nadia N.; Pollock, Bruce E.
- Abstract
Purpose: To clarify the role of stereotactic radiosurgery (SRS) for atypical meningiomas (AM). Methods: A retrospective analysis of 68 patients with AM having SRS from 1995 until 2019. Results: Nineteen patients (28%) had undergone prior external beam radiation therapy (EBRT) (median dose, 54 Gy). The median follow-up period was 52 months. Eighteen (26%), 17 (25%), and 33 (49%) patients received SRS as an upfront adjuvant (≤ 6 months), early salvage (7–18 months), or late salvage treatment (> 18 months), respectively. The 3-, 5-, and 10-year progression-free survivals (PFSs) were 52%, 35%, and 25%, respectively. The 3-, 5-, and 10-year disease-specific survivals were 85%, 78%, and 61%, respectively. Adverse radiation events (AREs) were observed in 12 patients (18%), with increased or new seizures being the most frequent complication (n = 7). Prior EBRT was associated with reduced PFS (HR 5.92, P < 0.01), reduced DSS (HR 5.84, P < 0.01), and an increased risk of ARE (HR 3.31, P = 0.04). Timing of SRS was correlated with reduced PFS for patients having early salvage treatment compared to upfront adjuvant (HR 3.17, P = 0.01) or late salvage treatment (HR 4.39, P < 0.01). Conclusion: PFS for patients with residual/recurrent AM remains poor despite SRS. Prior EBRT was associated with worse tumor control, higher tumor-related mortality, and an increased risk of ARE. Further study on the timing of SRS is needed to determine if upfront adjunctive SRS improves tumor control compared to salvage SRS.
- Subjects
STEREOTACTIC radiosurgery; RADIOSURGERY; EXTERNAL beam radiotherapy; EPILEPSY; PROGRESSION-free survival
- Publication
Journal of Neuro-Oncology, 2021, Vol 155, Issue 3, p335
- ISSN
0167-594X
- Publication type
Article
- DOI
10.1007/s11060-021-03882-9