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- Title
Use of FDG-PET/CT for systemic assessment of suspected primary central nervous system lymphoma: a LOC study.
- Authors
Bertaux, Marc; Houillier, Caroline; Edeline, Véronique; Habert, Marie-Odile; Mokhtari, Karima; Giron, Alain; Bergeret, Sébastien; Hoang-Xuan, Khe; Cassoux, Nathalie; Touitou, Valérie; Choquet, Sylvain; Soussain, Carole; Kas, Aurélie
- Abstract
Introduction: Primary Central Nervous System Lymphoma (PCNSL) is a rare disease with different therapeutic implications than systemic lymphoma. In this study, we evaluated whole-body 18FDG-PET/CT for pre-chemotherapy imaging of suspected PCNSL. Methods: One hundred and thirty consecutive immunocompetent patients were retrospectively included. The results of initial 18FDG-PET/CT, contrast-enhanced CT (CeCT) and bone marrow biopsy (BMB) when available were compared to a gold standard based on pathological diagnosis or follow-up. Results: CNS lesion pathology showed large B-cell lymphoma in 95% of patients, including 11 patients with primary vitro-retinal lymphoma. Ten patients (8%) where ultimately diagnosed with systemic lymphoma involvement, including five pathologically confirmed cases, all of which were detected by 18FDG-PET/CT. 18FDG-PET/CT showed incidental systemic findings unrelated to lymphoma in 14% of patients. An SUVmax threshold of nine enabled good discrimination between systemic lymphoma and other lesions (sensitivity 92% and specificity 89%). CeCT and BMB performed in 108 and 77 patients respectively revealed systemic lesions in only three patients. Conclusion: 18FDG-PET/CT detected concomitant occult systemic involvement in a non-negligible proportion of suspected PCNSL cases (8%). In this setting its sensitivity is higher than that of CeCT. All of our patients ultimately diagnosed with concomitant systemic involvement had positive 18FDG-PET/CT. We believe it constitutes a safe one-stop shop evaluation for the systemic pre-treatment imaging of suspected PCNSL.
- Subjects
CENTRAL nervous system; LYMPHOMAS; BONE marrow; DIFFUSE large B-cell lymphomas
- Publication
Journal of Neuro-Oncology, 2020, Vol 148, Issue 2, p343
- ISSN
0167-594X
- Publication type
Article
- DOI
10.1007/s11060-020-03525-5