We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Manganese enhanced magnetic resonance imaging of normal and ischemic canine heart.
- Authors
Hu, Tom C.-C.; Christian, Timothy F.; Aletras, Anthony H.; Taylor, Joni L.; Koretsky, Alan P.; Arai, Andrew E.
- Abstract
The ability of MnCl2 to enhance canine myocardium and to delineate ischemic areas is demonstrated. A dose-response curve was measured using T1 weighted images in 11 dogs. MnCl2 (36, 113, 360, and 3600 μmol) was infused over a period of 3 min. Signal intensity increased linearly with MnCl2 dose. At 113 μmol (∼10 μmol/kg) the steady-state increase in intensity averaged 212 ± 34%. No significant physiologic effects due to the infused MnCl2 were detected except at the highest dose where there was a cardiac depressive effect. Ischemia was induced by occluding the left anterior descending coronary artery in 5 dogs. At an infused dose of 113 μmol, MnCl2 clearly demarcated the ischemic zone during coronary occlusion. Contrast enhancement in the ischemic zone was less than 30% compared with normal tissue ( P < 0.03). In conclusion, the intracellular contrast agent MnCl2 enhances the canine heart and shows promise in detecting ischemia at doses that do not cause adverse cardiac effects. Magn Reson Med 54:196-200, 2005. Published 2005 Wiley-Liss, Inc.
- Publication
Magnetic Resonance in Medicine, 2005, Vol 54, Issue 1, p196
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.20516