We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
High-Loading Supports for Oligonucleotide Synthesis.
- Authors
Patnaik, Anupa K.; Subba Rao, N.; Kumar, Pradeep; Sharma, Ashwani K.; Garg, Bhagwan S.; Gupta, Kailash C.
- Abstract
A simple protocol for the preparation of high-loading supports, suitable for large-scale synthesis of oligonucleotides, has been developed. The method involves the use of inexpensive reagents and is amenable to large-scale preparation of supports. The derivatized supports were successfully employed in an automated DNA synthesizer without any difficulty. The quality of the synthesized oligonucleotides was found to be comparable to that of the corresponding oligomers prepared with commercially available standard supports.
- Publication
Helvetica Chimica Acta, 2000, Vol 83, Issue 2, p322
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/(SICI)1522-2675(20000216)83:2<322::AID-HLCA322>3.0.CO;2-A