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- Title
Tritium Labelling of Naltrindole, a δ-Receptor-Selective Opioid Antagonist via 1-Bromonaltrexone.
- Authors
Tóth, Géza; Ötvös, Ferenc; Hosztafi, Sándor
- Abstract
The synthesis of [1,5′-3H2]naltrindole ( 9) with labels at both the morphine skeleton and the indole moiety was carried out by catalytic tritiodehalogenation of 1,5′-dibromonaltrindole ( 8) resulting in a specific activity of 46.1 Ci/mmol (1705 GBq/mmol). The brominated precursor was prepared by the Fischer indole synthesis starting from 1-bromonaltrexone ( 7) and (4-bromophenyl)hydrazine.
- Publication
Helvetica Chimica Acta, 1993, Vol 76, Issue 6, p2274
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.19930760612