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- Title
Interaction between CTLA4 gene and IBD5 locus in Hungarian Crohn's disease patients.
- Authors
Csöngei, Veronika; Járomi, Luca; Sáfrány, Enikõ; Sipeky, Csilla; Magyari, Lili; Polgár, Noémi; Bene, Judit; Sarlós, Patrícia; Lakner, Lilla; Baricza, Eszter; Szabó, Melinda; Rappai, Gábor; Melegh, Béla
- Abstract
Backgrounds and aims: The IGR2198a_1 and IGR2096a_1 variants of the IBD5 region were found to be associated with Crohn's disease (CD) in the Hungarian population, while IGR2230a_1 does not seem to confer risk for the disease. In the present study, our aim was to investigate the statistical interaction of these three IBD5 polymorphisms with the +49 A/G substitution within the cytotoxic T lymphocyte antigen-4 ( CTLA4) gene, detected previously as neutral gene variant in Hungarian IBD patients. Methods: A total of 305 unrelated subjects with CD and 310 healthy controls were genotyped with PCR-RFLP methods. Results: In contrast with single gene effects, after genotype stratification, the IGR2198a_1 C and IGR2096a_1 T variants were found to confer susceptibility only in subjects with CTLA4 +49 AA genotype ( P = 0.008; OR = 1.86 and P = 0.016; OR = 1.74, respectively), for IGR2230a_1 no such effect on disease risk could be demonstrated. Conclusion: Analysis of specific genotype combinations unfolded a possible association between the CTLA4 +49 A/G substitution and two of the observed IBD5 variants with respect to disease risk.
- Subjects
CROHN'S disease; INFLAMMATORY bowel diseases; GENETICS of disease susceptibility; GENETIC research; COMBINATORICS; T cells
- Publication
International Journal of Colorectal Disease, 2011, Vol 26, Issue 9, p1119
- ISSN
0179-1958
- Publication type
Article
- DOI
10.1007/s00384-011-1202-z