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- Title
Frequent inactivating mutations of the PBAF complex gene PBRM1 in meningioma with papillary features.
- Authors
Williams, Erik A.; Wakimoto, Hiroaki; Shankar, Ganesh M.; Barker II, Fred G.; Brastianos, Priscilla K.; Santagata, Sandro; Sokol, Ethan S.; Pavlick, Dean C.; Shah, Nikunj; Reddy, Abhinav; Venstrom, Jeffrey M.; Alexander, Brian M.; Ross, Jeffrey S.; Cahill, Daniel P.; Ramkissoon, Shakti H.; Juratli, Tareq A.
- Abstract
Papillary meningioma (PM) is a World Health Organization (WHO) grade III tumor defined histologically by a perivascular pseudopapillary growth pattern across most of the tumor (> 50%) [[10]]. Our findings suggest that I BAP1 i mutations tend to occur in rhabdoid meningiomas whereas I PBRM1 i mutations tend to occur in papillary meningiomas, although genetic and histologic overlap is noted. Although our findings suggest that I PBRM1 i mutation is uncommon in meningioma, the inclusion of patients with this defined genetic subtype of meningioma in similar trials may reveal new therapeutic approaches. In conclusion, we identify the tumor suppressor gene I PBRM1 i as a recurrently altered gene in meningiomas with papillary histomorphology.
- Subjects
VOXEL-based morphometry; CENTRAL nervous system tumors
- Publication
Acta Neuropathologica, 2020, Vol 140, Issue 1, p89
- ISSN
0001-6322
- Publication type
Article
- DOI
10.1007/s00401-020-02161-7