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- Title
YAP1-fusions in pediatric NF2-wildtype meningioma.
- Authors
Sievers, Philipp; Chiang, Jason; Schrimpf, Daniel; Stichel, Damian; Paramasivam, Nagarajan; Sill, Martin; Gayden, Tenzin; Casalini, Belen; Reuss, David E.; Dalton, James; Pajtler, Kristian W.; Hänggi, Daniel; Herold-Mende, Christel; Rushing, Elisabeth; Korshunov, Andrey; Mawrin, Christian; Weller, Michael; Schlesner, Matthias; Wick, Wolfgang; Jabado, Nada
- Abstract
1 a Unsupervised hierarchical clustering of DNA methylation profiles in nine YAP1-fused meningiomas (MNG YAP1) alongside 128 well-characterized CNS neoplasms and control tissue shown in a two-dimensional representation of pairwise sample correlations using the 15,000 most variant probes by t-distributed stochastic neighbor embedding (t-SNE) dimensionality reduction. Histological meningioma subtypes meningiomas and WHO grade are provided in Supplementary Table 2 I MNG i meningioma, I PXA i pleomorphic xanthoastrocytoma, I pHGG i pediatric high grade glioma, I F i female, I M i male Seven tumors harbored a rearrangement of I YAP1-MAML2 i involving exons 1-5 ( I n i = 5) or only in exon 1 ( I n i = 2) of I YAP1 i (NM 001130145) and exon 2-5 of I MAML2 i (NM 032427) I . In line, I YAP1 i fusion positive meningiomas clustered closer to I NF2 i mutant cases than other pediatric meningiomas (Online Resource Supplementary Fig.
- Subjects
FLUORESCENCE in situ hybridization
- Publication
Acta Neuropathologica, 2020, Vol 139, Issue 1, p215
- ISSN
0001-6322
- Publication type
Letter
- DOI
10.1007/s00401-019-02095-9