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- Title
Low rate of R132H IDH1 mutation in infratentorial and spinal cord grade II and III diffuse gliomas.
- Authors
Ellezam, Benjamin; Theeler, Brett; Walbert, Tobias; Mammoser, Aaron; Horbinski, Craig; Kleinschmidt-DeMasters, Bette; Perry, Arie; Puduvalli, Vinay; Fuller, Gregory; Bruner, Janet; Aldape, Kenneth
- Abstract
The article presents a study on the mutation of R132H mutant isocitrate dehydrogenase 1 (mIDH1) in infratentorial and spinal cord grade II and III diffuse gliomas. The analysis of R132H mIDHI has been shown to distinguish diffuse astrocytomas from some of their most frequent mimickers. The low rate of R312H IDH1 mutation is in contrast with the high rate seen in same grade diffuse gliomas in the supratentorial compartment.
- Subjects
GENETIC mutation; DEHYDROGENASES; SPINAL cord; GLIOMAS; ASTROCYTOMAS
- Publication
Acta Neuropathologica, 2012, Vol 124, Issue 3, p449
- ISSN
0001-6322
- Publication type
Letter
- DOI
10.1007/s00401-012-1011-7