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- Title
Induction of the complement component C1qB in brain of transgenic mice with neuronal overexpression of human cyclooxygenase-2.
- Authors
Spielman, Lauren; Winger, David; Ho, Lap; Aisen, Paul S.; Shohami, Esther; Pasinetti, Giulio Maria
- Abstract
We report that overexpression of human (h) cyclooxygenase-2 h(COX-2) in the brain of a transgenic mouse line leads to selective induction of endogenous complement component C1qB expression in neurons. No detectable induction of the C3 and C4 complement components in the brain was found. Chronic treatment of mice with the selective COX-2 inhibitor nimesulide reduced the hCOX-2-mediated induction of hippocampal C1qB mRNA expression. The data suggest that neuronal COX-2 expression may influence inflammatory responses in the brain, in part through modulation of complement gene expression. Because there is extensive evidence that C1q and other complement components are involved in Alzheimer's disease (AD) neurodegeneration, this study advances our understanding of the apparent benefits of COX-2 inhibition in AD.
- Subjects
CYCLOOXYGENASES; OXIDOREDUCTASES; ALZHEIMER'S disease; PRESENILE dementia; HIPPOCAMPUS (Brain); NEURODEGENERATION
- Publication
Acta Neuropathologica, 2002, Vol 103, Issue 2, p157
- ISSN
0001-6322
- Publication type
Article
- DOI
10.1007/s004010100447