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- Title
Efficacy of Oral Cytarabine Ocfosfate and Etoposide in the Treatment of Elderly Patients with Higher-Risk Myelodysplastic Syndromes Compared to That in Elderly Acute Myeloid Leukemia Patients.
- Authors
Horikoshi, Akira; Iriyama, Noriyoshi; Hirabayashi, Yukio; Kodaira, Hitomi; Matsukawa, Yoshihiro; Uchino, Yoshihito; Takahashi, Hiromichi; Hatta, Yoshihiro; Takeuchi, Jin; Kobayashi, Sumiko; Miura, Katsuhiro
- Abstract
Background: Elderly acute myeloid leukemia (AML) patients and patients with higher-risk myelodysplastic syndromes (MDS) have a much poorer prognosis than younger patients despite intensive chemotherapy. Methods: Ten patients with higher-risk MDS and 12 patients with AML over 65 years of age were enrolled into this study and received oral induction therapy with cytarabine ocfosfate and etoposide. Results: The therapy response rates were 60% in the MDS group and 41.7% in the AML group. The difference in overall survival among MDS and AML patients was not statistically significant. The difference in the median survival times of the responsive and nonresponsive groups, which included MDS and AML patients, was statistically significant (790 and 174 days, respectively). Conclusions: Based on a comparison of the data of this therapy in elderly higher-risk MDS patients versus elderly AML patients, we conclude that this therapy is well tolerated and can be cost-effective and useful for higher-risk MDS in elderly patients. © 2013 S. Karger AG, Basel
- Subjects
CYTARABINE; ETOPOSIDE; MYELODYSPLASTIC syndromes treatment; OLDER patients; ACUTE myeloid leukemia; COMPARATIVE studies; MYELODYSPLASTIC syndromes; PATIENTS; PROGNOSIS; DISEASE risk factors
- Publication
Chemotherapy (0009-3157), 2013, Vol 59, Issue 2, p152
- ISSN
0009-3157
- Publication type
Article
- DOI
10.1159/000351114