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- Title
Bayesian model averaging for the X-chromosome inactivation dilemma in genetic association study.
- Authors
Chen, Bo; Craiu, Radu V; Sun, Lei
- Abstract
X-chromosome is often excluded from the so called "whole-genome" association studies due to the differences it exhibits between males and females. One particular analytical challenge is the unknown status of X-inactivation, where one of the two X-chromosome variants in females may be randomly selected to be silenced. In the absence of biological evidence in favor of one specific model, we consider a Bayesian model averaging framework that offers a principled way to account for the inherent model uncertainty, providing model averaging-based posterior density intervals and Bayes factors. We examine the inferential properties of the proposed methods via extensive simulation studies, and we apply the methods to a genetic association study of an intestinal disease occurring in about 20% of cystic fibrosis patients. Compared with the results previously reported assuming the presence of inactivation, we show that the proposed Bayesian methods provide more feature-rich quantities that are useful in practice.
- Subjects
MARKOV chain Monte Carlo; DILEMMA; INTESTINAL diseases; BIOLOGICAL models; CHROMOSOMES; COMPARATIVE studies; COMPUTER simulation; CYSTIC fibrosis; GENETIC techniques; RESEARCH methodology; MEDICAL cooperation; PROBABILITY theory; RESEARCH; EVALUATION research; STATISTICAL models; DISEASE complications
- Publication
Biostatistics, 2020, Vol 21, Issue 2, p319
- ISSN
1465-4644
- Publication type
journal article
- DOI
10.1093/biostatistics/kxy049