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- Title
Evaluation of Antibody Levels and Certain Biochemical Parameters in the Patients Infected with SARS-COV-2.
- Authors
ASLAN, Özgür; SAMANCI AKTAR, Gülseren; MIZRAKLI, Ayser; RAHMANALI ONUR, Arzu; DURAK, Mehmet Hanifi
- Abstract
Objective: In cases with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease clinical usefulness of serological tests remains uncertain. The study aimed to evaluate anti-SARSCoV-2 antibody and some biochemical parameters such as leukocyte (WBC), neutrophil (NEU), lymphocyte (LYM), thrombocyte (PLT), erythrocyte (RBC), hemoglobin (Hb), ferritin, procalcitonin (PCT), C-reactive protein (CRP) and D-dimer in the patient specimens sent from the polyclinic and service/intensive care unit. Materials and Methods: A total of 110 patients' specimens sent from the polyclinic and from the service/intensive care unit were used. SARS-CoV-2 RT PCR, immunoassay SARS-CoV-2 antibody and other biochemical tests were assessed. Results: Anti-SARS-CoV-2 antibody was positive in 11 (5 polyclinic, 6 service/intensive care) of 24 patients with negative RT-PCR test. Significant difference was determined between the two groups from the polyclinic and service/intensive care unit in terms of WBC, NEU, RBC and Hb, ferritin, CRP, PCT and D-dimer levels (p= 0.001, 0.007, 0.002, 0.006, 0.001, <0.001, 0.012 and 0.001, respectively), whereas other parameters (lymphocyte, platelet) showed no significant difference. Conclusions: Because of gradually increasing rate of exposure to SARS-CoV-2, we suggest that seroprevalence needs to be determined, antibody levels should be identified before vaccination, and antibody should be studied in the symptomatic patients with negative RT-PCR.
- Subjects
SARS-CoV-2; SEROLOGY; CALCITONIN; C-reactive protein; INTENSIVE care units; IMMUNOASSAY
- Publication
Firat Universitesi Sağlik Bilimleri Tip Dergisi, 2022, Vol 36, Issue 1, p19
- ISSN
1308-9315
- Publication type
Article