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- Title
Oral Baclofen Therapy for Multifocal Spinal Myoclonus with TBC1D24 Variant.
- Authors
Murofushi, Yuka; Hayakawa, Itaru; Kawai, Michiko; Abe, Yuichi; Kosaki, Rika; Suzuki, Hisato; Takenouchi, Toshiki; Kubota, Masaya
- Abstract
Keywords: TBC1D24; spinal myoclonus; baclofen; surface electromyography EN TBC1D24 spinal myoclonus baclofen surface electromyography 719 721 3 04/18/23 20230401 NES 230401 I TBC1D24 i (#MIM 613577) variants-associated diseases include a wide spectrum of epilepsy, drug-resistant multifocal myoclonus, and epilepsia partialis continua.[[1]] Reports of abdominal myoclonus[3] and no scalp electroencephalogram (EEG) correlation during myoclonus[1] have suggested concomitant myoclonus of non-cortical origin, but no report has proven this. Multiple prolonged EEGs showed no epileptiform abnormalities and no EEG correlation with myoclonus, except for an episode at 1 year and 6 months when the patient had widespread polymyoclonus in a febrile state that lasted several hours. Surface electromyography showed that myoclonus simultaneously spread rostrally and caudally, and it was judged to be spinal myoclonus (Fig.
- Subjects
MYOCLONUS; BACLOFEN; LATISSIMUS dorsi (Muscles)
- Publication
Movement Disorders Clinical Practice, 2023, Vol 10, Issue 4, p719
- ISSN
2330-1619
- Publication type
Article
- DOI
10.1002/mdc3.13701