We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Metabolism‐based therapies for epilepsy: new directions for future cures.
- Authors
Cervenka, Mackenzie; Pascual, Juan M.; Rho, Jong M.; Thiele, Elizabeth; Yellen, Gary; Whittemore, Vicky; Hartman, Adam L.
- Abstract
Objective: Thousands of years after dietary therapy was proposed to treat seizures, how alterations in metabolism relates to epilepsy remains unclear, and metabolism‐based therapies are not always effective. Methods: We consider the state of the science in metabolism‐based therapies for epilepsy across the research lifecycle from basic to translational to clinical studies. Results: This analysis creates a conceptual framework for creative, rigorous, and transparent research to benefit people with epilepsy through the understanding and modification of metabolism. Interpretation: Despite intensive past efforts to evaluate metabolism‐based therapies for epilepsy, distinct ways of framing a problem offer the chance to engage different mindsets and new (or newly applied) technologies. A comprehensive, creative, and inclusive problem‐directed research agenda is needed, with a renewed and stringent adherence to rigor and transparency across all levels of investigation.
- Subjects
EPILEPSY; PEOPLE with epilepsy; SEIZURES (Medicine)
- Publication
Annals of Clinical & Translational Neurology, 2021, Vol 8, Issue 8, p1730
- ISSN
2328-9503
- Publication type
Article
- DOI
10.1002/acn3.51423