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- Title
Severe cryptococcal-associated neurological immune reconstitution inflammatory syndrome in a renal transplant recipient treated with adalimumab.
- Authors
Deshayes, S.; Bouvier, N.; Chatelet, V.; Hurault de Ligny, B.; Dargère, S.; Bonhomme, J.; Béchade, C.
- Abstract
Cryptococcosis is a major concern in organ transplant recipients. A decrease in immunosuppressants following the initiation of antifungal therapy is currently recommended, but can occasionally be complicated by the onset of immune reconstitution inflammatory syndrome ( IRIS). We report on a case of cryptococcosis in a kidney transplant recipient, compounded by severe neurological IRIS, the outcome of which was unfavorable despite the use of anti-tumor necrosis factor-alpha monoclonal antibodies.
- Subjects
CRYPTOCOCCALES; IMMUNE reconstitution inflammatory syndrome; KIDNEY transplant patients; ADALIMUMAB; CRYPTOCOCCOSIS; ANTINEOPLASTIC agents; TUMOR necrosis factors
- Publication
Transplant Infectious Disease, 2016, Vol 18, Issue 3, p461
- ISSN
1398-2273
- Publication type
Article
- DOI
10.1111/tid.12522