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- Title
Ym1 and Ym2 Expression in a Mouse Model Exposed to Diesel Exhaust Particles.
- Authors
Hyun-Mi Song; An-Soo Jang; Mi-Hyun Ahn; Takizawa, Hajime; Shin-Hwa Lee; Ji-Hee Kwon; Young-Mok Lee; TaiYoun Rhim; Choon-Sik Park
- Abstract
This article discusses the possible role of chitinase in regulating allergies in a mouse model exposed to diesel exhaust. The authors measured the expression of Ym1 and Ym2 mRNA in lung tissues by reverse transcription-polymerase chain reaction. They concluded that diesel exhaust particles induced Ym mRNA expression via a Th2 cell-biased response and airway hyperresponsiveness suggesting that chitinase may play an important role in responsiveness and airway inflammation and therefore may be involved in regulating allergic diseases.
- Subjects
ALLERGIES; DIESEL motor exhaust gas; CHITINASE; MICE; MESSENGER RNA; DNA polymerases; POLYMERASE chain reaction; TH2 cells; GENE expression; ASTHMA
- Publication
Environmental Toxicology, 2008, Vol 23, Issue 1, p110
- ISSN
1520-4081
- Publication type
Article
- DOI
10.1002/tox.20319