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- Title
Non-specific irreversible <sup>89</sup>Zr-mAb uptake in tumours: evidence from biopsy-proven target-negative tumours using <sup>89</sup>Zr-immuno-PET.
- Authors
Wijngaarden, Jessica E.; Jauw, Yvonne W. S.; Zwezerijnen, Gerben J. C.; de Wit-van der Veen, Berlinda J.; Vugts, Daniëlle J.; Zijlstra, Josée M.; van Dongen, Guus A. M. S.; Boellaard, Ronald; Menke-van der Houven van Oordt, C. Willemien; Huisman, Marc C.
- Abstract
Background: Distribution of mAbs into tumour tissue may occur via different processes contributing differently to the 89Zr-mAb uptake on PET. Target-specific binding in tumours is of main interest; however, non-specific irreversible uptake may also be present, which influences quantification. The aim was to investigate the presence of non-specific irreversible uptake in tumour tissue using Patlak linearization on 89Zr-immuno-PET data of biopsy-proven target-negative tumours. Data of two studies, including target status obtained from biopsies, were retrospectively analysed, and Patlak linearization provided the net rate of irreversible uptake (Ki). Results: Two tumours were classified as CD20-negative and two as CD20-positive. Four tumours were classified as CEA-negative and nine as CEA-positive. Ki values of CD20-negative (0.43 µL/g/h and 0.92 µL/g/h) and CEA-negative tumours (mdn = 1.97 µL/g/h, interquartile range (IQR) = 1.50–2.39) were higher than zero. Median Ki values of target-negative tumours were lower than CD20-positive (1.87 µL/g/h and 1.90 µL/g/h) and CEA-positive tumours (mdn = 2.77 µL/g/h, IQR = 2.11–3.65). Conclusion: Biopsy-proven target-negative tumours showed irreversible uptake of 89Zr-mAbs measured in vivo using 89Zr-immuno-PET data, which suggests the presence of non-specific irreversible uptake in tumours. Consequently, for 89Zr-immuno-PET, even if the target is absent, a tumour-to-plasma ratio always increases over time.
- Subjects
TUMORS; POSITRON emission tomography
- Publication
EJNMMI Research, 2024, Vol 14, p1
- ISSN
2191-219X
- Publication type
Article
- DOI
10.1186/s13550-024-01079-5