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- Title
Focal Ischemic Preconditioning Induces Rapid Tolerance to Middle Cerebral Artery Occlusion in Mice.
- Authors
Stagliano, Nancy E; Pérez-Pinzón, Miguel A; Moskowitz, Michael A; Huang, Paul L
- Abstract
SummaryIn a process called ischemic preconditioning, a brief, sublethal ischemic insult protects tissue from subsequent, more severe injury. There have been no reports of rapidly induced ischemic preconditioning. The authors sought to develop a model of cerebral ischemic preconditioning in the mouse that can be applied to transgenic and knockout animals. They found that brief middle cerebral artery (MCA) occlusion only minutes before a severe ischemic insult can induce protection from that insult. Here the investigators describe a mouse model of preconditioning using intraluminal MCA occlusion as both the conditioning and the test stimulus. One or three 5-minute episodes of ischemia given 30 minutes before MCA occlusion for 1 or 24 hours (permanent occlusion) confer significant protection as assessed by infarct volume measurements 24 hours later.Journal of Cerebral Blood Flow & Metabolism (1999) 19, 757-761; doi:10.1097/00004647-199907000-00005
- Publication
Journal of Cerebral Blood Flow & Metabolism, 1999, Vol 19, Issue 7, p757
- ISSN
0271-678X
- Publication type
Article
- DOI
10.1097/00004647-199907000-00005