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- Title
Analgesic effects of nerve growth factor-directed monoclonal antibody on diabetic neuralgia in an animal model.
- Authors
Xingchen Dong; Huanhuan Li; Min Pei; Jie Tan; Ganjun Chen; Santai Li; Zuobin Xie; Qi Wang; Guifeng Wang; Yi-Li Chen; Chunhe Wang
- Abstract
Current treatment options for diabetic neuralgia are limited and unsatisfactory. Tanezumab, a monoclonal antibody that blocks nerve growth factor (NGF) signaling, has been shown to be effective in relieving the clinical symptoms of osteoarthritis pain, chronic low back pain, cancer pain induced by bone metastasis, and diabetic neuralgia. However, the clinical development of tanezumab has been terminated due to the risk of induction of rapidly progressive osteoarthritis (RPOA), and no other NGF antibodies have been examined for their ability to treat diabetic neuralgia in either animal models or clinical trials. In this study, a humanized highaffinity NGF monoclonal antibody (mAb), huAb45 that could neutralize the interaction between NGF and its high-affinity receptor TrkA. In a mouse diabetic neuralgia model, it effectively relieved neuropathic pain. This study may serve as the necessary foundation for future studies of huAb45 to potentially treat diabetic neuralgia.
- Subjects
MONOCLONAL antibodies; NERVE growth factor; CHRONIC pain; NEURALGIA; ANIMAL models in research; CANCER pain
- Publication
FEBS Open Bio, 2022, Vol 12, Issue 7, p1325
- ISSN
2211-5463
- Publication type
Article
- DOI
10.1002/2211-5463.13410