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- Title
The human Mi-2/NuRD complex and gene regulation.
- Authors
Denslow, S. A.; Wade, P. A.
- Abstract
The Mi-2/nucleosome remodeling and deacetylase (NuRD) complex is an abundant deacetylase complex with a broad cellular and tissue distribution. It is unique in that it couples histone deacetylation and chromatin remodeling ATPase activities in the same complex. A decade of research has uncovered a number of interesting connections between Mi-2/NuRD and gene regulation. The subunit composition of the enzyme appears to vary with cell type and in response to physiologic signals within a tissue. Here, we review the known subunits of the complex, their connections to signaling networks, and their association with cancer. In addition, we propose a working model that integrates the known biochemical properties of the enzyme with emerging models on how chromatin structure and modification relate to gene activity.Oncogene (2007) 26, 5433–5438; doi:10.1038/sj.onc.1210611
- Subjects
HISTONE deacetylase; CHROMATIN; GENETIC regulation; GENE expression; ADENOSINE triphosphatase; G proteins
- Publication
Oncogene, 2007, Vol 26, Issue 37, p5433
- ISSN
0950-9232
- Publication type
Article
- DOI
10.1038/sj.onc.1210611