We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Polyacrylate–Cholesterol Amphiphilic Derivative: Formulation Development and Scale-up for Health Care Applications.
- Authors
Viola, Marco; Migliorini, Claudia; Ziarelli, Fabio; Viel, Stéphane; Cencetti, Claudia; Di Risola, Daniel; Mosca, Luciana; Masuelli, Laura; Matricardi, Pietro; Di Meo, Chiara
- Abstract
The novel amphiphilic polyacrylate grafted with cholesterol moieties, PAAbCH, previously synthesized, was deeply characterized and investigated in the lab and on a pre-industrial scale. Solid-state NMR analysis confirmed the polymer structure, and several water-based pharmaceutical and cosmetic products were developed. In particular, stable oil/water emulsions with vegetable oils, squalene, and ceramides were prepared, as well as hydrophilic medicated films loaded with diclofenac, providing a prolonged drug release. PAAbCH also formed polyelectrolyte hydrogel complexes with chitosan, both at the macro- and nano-scale. The results demonstrate that this polymer has promising potential as an innovative excipient, acting as a solubility enhancer, viscosity enhancer, and emulsifying agent with an easy scale-up transfer process.
- Subjects
VEGETABLE oils; POLYMER structure; MEDICAL care; CERAMIDES; MOIETIES (Chemistry); POLYMERS
- Publication
Journal of Functional Biomaterials, 2023, Vol 14, Issue 9, p482
- ISSN
2079-4983
- Publication type
Article
- DOI
10.3390/jfb14090482