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- Title
An Inverse Correlation between Interleukin-6 and Select Gene Promoter Methylation in Patients with Gastric Cancer.
- Authors
Li Ping Tang; Chi Hin Cho; Wai Mo Hui; Camy Huang; Kent Man Chu; Harry H. X. Xia; Shiu Kum Lam; Rashid, Asif; Wong, Benjamin C. Y.; On On Chan, Annie
- Abstract
Background: Both serum IL-6 levels and CpG island methylation have been shown to have prognostic significance in gastric cancer, it was suggested that an important link existed between IL-6 and methylation of cancers. Aim: To investigate the prognostic value of IL-6 serum level and the association between serum IL-6 levels and CpG island methylation at p16, DAPK, MGMT and E-cadherin in patients with gastric cancer. Patients and Methods: Methylation status was assessed by MSP in 75 surgical specimens of gastric adenocarcinoma. IL-6 serum levels were measured by chemiluminescent enzyme immunoassay (CLEIA). Results: Methylation of p16, DAPK, MGMT, and E-cadherin were present in 53, 48, 32, and 59% of patients. Patients with tumors methylated at p16 and DAPK had lower serum levels of IL-6 compared to unmethylated tumors (1.8 vs. 4.8 pg/ml, p = 0.01 for p16; 1.5 vs. 6.2 pg/ml, p = 0.0001 for DAPK). But there was no difference with MGMT and E-cadherin methylation status. Serum IL-6 levels were also associated with TNM stage (p = 0.001), depth of tumor invasion (p = 0.002), lymphatic invasion (p = 0.01), vascular invasion (p = 0.008), metastasis (p = 0.002) and signet cell histology (p = 0.001). Conclusion: IL-6 is of prognostic value for patients of gastric cancer. Low serum IL-6 levels were associated with p16 or DAPK gene methylation in patients with gastric cancer. Copyright © 2006 S. Karger AG, Basel
- Subjects
INTERLEUKIN-6; METHYLATION; STOMACH cancer; ADENOCARCINOMA; CHEMILUMINESCENCE assay
- Publication
Digestion, 2006, Vol 74, Issue 2, p85
- ISSN
0012-2823
- Publication type
Article
- DOI
10.1159/000097623