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- Title
Silver‐Promoted Decarboxylative Difluoromethylenation of α,β‐Unsaturated Carboxylic Acids for the Synthesis of Allylic Difluorides.
- Authors
Li, Hongxiao; Sun, Qianqian; Zhang, TianTian; Chen, Yunrong; Zhang, Jianhua; Deng, Hongmei; Jiang, Haizhen
- Abstract
An efficient silver‐promoted decarboxylative gem‐difluoromethylenation of aryl‐ or alkyl‐substituted α,β‐unsaturated carboxylic acids with readily available benzo‐1,3‐diazolic difluoromethyl bromides has been developed. This convenient transformation demonstrated good functional‐group tolerability and broad substrate scope, and afforded the allylic difluorides in good to excellent yields with exclusive E‐stereoselectivity under mild reaction conditions.
- Subjects
CARBOXYLIC acids; ARYL bromides; BROMIDES
- Publication
Chemistry - An Asian Journal, 2022, Vol 17, Issue 15, p1
- ISSN
1861-4728
- Publication type
Article
- DOI
10.1002/asia.202200448