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- Title
The preventive effect of magnesium sulfate on lung injury due to pneumoperitoneum in experimental laparoscopic model.
- Authors
Yörük, Fatih; Geze, Şükran; Tusat, Mustafa; Menteşe, Ahmet; Yuluğ, Esin; Beyazta???Emre; Alver, Ahmet
- Abstract
Background: Although laparoscopy was regarded as a minimally invasive technique compared to open surgery, experimental and clinical studies in recent years have revealed that rises in intra-abdominal pressure (IAP) in association with degree of pneumoperitoneum (PP) established may lead to hypoperfusion, particularly in the abdominal organs. Our purpose in this study was to investigate the effect of MgSO4 in preventing pulmonary injury after PP. Methods: Eighteen female Sprague-Dawley rats (weight 240-280 g) were divided into three groups. In Group I (n=6), rats were ventilated only, and no PP was established. In Group II (n=6), PP was established for 60 min under 12 mmHg pressure, while in Group III (n=6) 90 mg/kg MgSO4 was administered IP 30 min before 60-min PP at 12 mmHg. Blood and lung specimens from groups 2 and 3 were taken 30 min after abdominal desufflation following 60-min PP, and from Group 1 after 90-min ventilation. Plasma ischemia modified albumin (IMA) was measured. Lung tissue was examined histopathologically. Results: Plasma IMA levels were significantly higher in Group II compared to the other groups. Plasma IMA levels in Group III, administered MgSO4, decreased significantly compared to the PP group. Various significant reperfusion injury-related changes were observed at histopathological examination in Group II. Widespread inter- and intraalveolar hemorrhage, vascular congestion and alveolar edema were present in the PP group (Group II) preparates. Peribronchial inflammatory cell infiltration and pronounced degeneration in alveolar architecture were observed. Alveolar hemorrhage was significantly lower in the preparates containing tissue sections from the magnesium sulfate group (Group III) compared to the PP group. Alveolar architecture was close to normal. Vascular congestion was moderate, and the alveolar edema seen in the PP group was not observed. Conclusion: We determined that IR-related injury developing after PP causes injury in the lung in ventilated rats. IMA levels were significantly decreased in histopathological examination of lung tissue and in plasma. In conclusion the administration of MgSO4 in pulmonary injury arising due to PP may have important effects in reducing IR injury.
- Publication
Journal of Harran University Medical Faculty / Harran Üniversitesi Tıp Fakültesi Dergisi, 2012, Vol 9, Issue 3, p92
- ISSN
1304-9623
- Publication type
Journal Article