We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
AML-179: Seasonal Association of Acute Promyelocytic Leukemia: A 6-Year Single-Center Experience.
- Authors
Cömert, Melda; Güneş, Ebru Kılıç; Yıldırım, Murat; Uğur, Bilge; Sayın, Selim; Bulduk, Tuba; Merdin, Alparslan; Karakulak, Elifcan Aladağ; Aylı, Meltem
- Abstract
Oncogenes, pollution, infections, or the dysregulation of the immune system can be triggering factors for leukemias, but there is not a specific factor for acute promyelocytic leukemia (APL). Investigating the impacts of seasonality in the incidence of APL in our center and its characteristics were the aims of the study. Six-year records of 21 APL patients who were diagnosed and treated in Gülhane Education and Training Hospital from 2015 to 2021 were evaluated retrospectively. Patients were categorized on the basis of the seasons in which they were diagnosed: winter (December–February), spring (March–May), summer (June–August), and autumn (September–November). The mean age of the patients was 47.7 years (30–79) M/F: 3/1. Seven patients (33.3%) were diagnosed in winter, 7 patients (33.3%) in autumn, 5 patients in spring (23.8%), and 2 patients (9.5%) in summer. There was a significant difference in terms of APL incidence in winter and autumn versus summer. Seasonal variations in hematologic diseases and leukemias have been largely reported by several epidemiological studies. In contrast to our study, Hassan et al. could not find any seasonal variations in APL. A Brazilian study reported a correlation between rainfall and APL. Timonen hypothesized that viral infections, sunlight deficiency, and cold temperatures could be effective for triggering leukemias. Acute myeloblastic leukemia (AML) showed the highest risk during dark seasons, which can be explained by vitamin D insufficiency. Parallel to this study, we can explain that decreased sun exposure in winter and autumn can trigger vitamin D deficiency and APL occurrence. Similarly, elevated viral infections can trigger leukemogenesis in winter. Supplementation with vitamin D and vaccination against influenza may be beneficial to prevent APL occurrence.
- Publication
Clinical Lymphoma, Myeloma & Leukemia, 2021, Vol 21, pS287
- ISSN
2152-2650
- Publication type
Article
- DOI
10.1016/S2152-2650(21)01689-X