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- Title
Evaluation of Parameters Related to the Probability of Leukemic Progression in Patients With Lower-Risk Myelodysplastic Syndrome.
- Authors
Falantes, Jose F.; Márquez-Malaver, Francisco J.; Calderón-Cabrera, Cristina; Pedrote, Begoña; Martino, María L.; González, Jose; Espigado, Ildefonso; Pérez-Simón, Jose A.; Márquez-Malaver, Francisco J; Calderón-Cabrera, Cristina; Pedrote, Begoña; Martino, María L; González, Jose; Pérez-Simón, Jose A
- Abstract
<bold>Background: </bold>The prognosis of patients with lower-risk myelodysplastic syndrome (LR-MDS) is very heterogeneous. In addition to survival estimates, identification of factors related to the probability of leukemic progression might help prognosis assessment.<bold>Patients and Methods: </bold>The present study is a retrospective analysis of 409 patients with primary LR-MDS. The probability of leukemic progression was estimated in the competing risk framework by the cumulative incidence method considering death without acute myeloid leukemia (AML) as a competing event.<bold>Results: </bold>Sixty-six patients (16.1%) progressed to AML. The following covariates influenced the probability of leukemic progression in a multivariate competing risk regression model: intermediate karyotype versus diploid or chromosome 5 deletion, 5% to 9% bone marrow blast percentage, platelet count <50 × 10e9/L and age younger than 75 years.<bold>Conclusion: </bold>According to these, a predictive model is proposed, which categorizes patients with different probability of leukemic progression (P < .001). Validation of these results might help prognostic refinement of patients with LR-MDS.
- Publication
Clinical Lymphoma, Myeloma & Leukemia, 2018, Vol 18, Issue 7, p469
- ISSN
2152-2650
- Publication type
journal article
- DOI
10.1016/j.clml.2018.05.004