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- Title
CORTICAL ACTIVITY AND HEART RATE CHANGES AS MARKERS OF NOXIOUS STIMULATION RESPONSE DURING CHLORAL HYDRATE ANESTHESIA.
- Authors
B., PAVEL; A., DĂNEASA; A., CĂLIN; A. M., RĂDULESCU; A. E., ROSCA; R. I., BRAGA; D., ZAHIU; L., ZĂGREAN
- Abstract
The aim of our study was to evaluate the importance and applicability of cortical activity and heart rate changes as markers of noxious stimulation response during chloral hydrate anaesthesia in rats. In this study we used a group of 11 Wistar rats, which were chronically implanted, with electrodes being placed on the dura mater of the right hemisphere, over the olfactory cortex (reference), the frontal and the parietal lobes. A noxious mechanical stimulus was applied on the left hindpaw during chloral hydrate anesthesia, at an anesthetic depth of 2-3 Hz, estimated using the median frequency. We assessed the electrical activity of the cortical areas (evaluated through median frequency, delta power and cortical connectivity between frontal and parietal cortex) and heart rate response to mechanical noxious stimulation. After data processing and analysis we observed an increase of median frequency and a decrease of delta power during the application of the noxious stimulus in both areas (frontal and parietal). No difference between fronto-parietal connectivity during baseline and stimulation tracks was noted. Tachogram analysis showed a mild increase in heart rate during noxious stimulation, but it did not reach statistic significance. Monitoring cortical electric activity is a better choice than ECG monitoring for noxious stimulation response assessment during chloral hydrate anesthesia in rat.
- Subjects
HEART beat; NEURAL stimulation; CHLORAL
- Publication
Physiology / Fiziologia, 2013, Vol 23, Issue 4, p22
- ISSN
1223-2076
- Publication type
Article