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- Title
Impact of Cilostazol on the Progression of Carotid Atherosclerosis in Patients with Retinal Vascular Occlusion.
- Authors
Kim, Seong‐Man; Cho, Kyoung‐Im
- Abstract
Background Cilostazol, a selective phosphodiesterase three inhibitor, has been proposed to have beneficial effects in the prevention of atherosclerosis. Aims We aimed to investigate the effects of cilostazol on carotid intima-media thickening ( IMT) and total plaque area ( TPA) in patients with retinal vascular occlusion. Methods A total of 63 consecutive vascular occlusive retinopathy patients with carotid atherosclerosis were enrolled. We examined changes in the carotid IMT/ TPA and visual acuity/macular thickness before and after 1-year treatment with cilostazol (200 mg/day). Results The mean IMT of both common carotid arteries ( CCAs) and internal carotid arteries ( ICAs) were significantly reduced after cilostazol treatment. There was no significant difference in the TPA of both CCAs before and after the treatment (before; 0.61 ± 0.94 vs. after; 0.45 ± 0.79 cm2, P = 0.291); however, significant plaque regression (before; 0.14 ± 0.15 vs. after; 0.25 ± 0.14 cm2, P = 0.004) was observed in selected patients (n = 30) with a TPA <0.5 cm2. The improvement in macular thickness was significantly associated with an improvement in carotid IMT (r = 0.42, P = 0.001) and TPA (r = 0.23, P = 0.04). Conclusion Cilostazol potently inhibited the progression of carotid IMT and may play a role in the early carotid plaque regression in patients with retinal vascular occlusion.
- Subjects
ATHEROSCLEROSIS treatment; PHOSPHODIESTERASE inhibitors; CAROTID intima-media thickness; DISEASE progression; ARTERIAL occlusions; RETINAL diseases; VISUAL acuity; ATHEROSCLEROTIC plaque; PATIENTS; THERAPEUTICS
- Publication
Cardiovascular Therapeutics, 2013, Vol 31, Issue 6, pe94
- ISSN
1755-5914
- Publication type
Article
- DOI
10.1111/1755-5922.12042