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- Title
Validación de la escala PRIDE (Primary Immunodeficiency Disease Evaluation) para determinar nivel alto de sospecha de inmunodeficiencia primaria en población mexicana.
- Authors
Mogica-Martínez, María D.; Vázquez-Leduc, Arturo; Ortega-Martell, José Antonio; Gómez-Alonso, Carlos; Rodriguez-Orozco, Alain R.; Rico-Arroyo, Marisol; Becerril-Ángeles, Martín
- Abstract
Background: Primary immunodeficiencies have a low prevalence, but their severity and high risk of mortality require a clinical approach based in diagnostic instruments that allow their early detection. Objective: To validate the PRIDE scale to determine a high level of suspicion for primary immunodeficiency diseases in Mexican population. Methods: Seventy five patients with suspicion of primary immunodeficiencies (13.9 ±11.8 years-old) were evaluated with the PRIDE scale by specialists in Allergy and Immunology in this cross-sectional study, and their results were compared with the confirmed diagnosis of primary immunodeficiency. Results: Kappa concordance coefficient with clinical diagnosis was 0.872, with an standard error of 0.072; CI 95% [0.73-1.013]. The scale showed sensitivity 98.3%, specificity 86.6%, positive predictive value 96.7%, negative predictive value 92.8%, positive odds ratio 7.3358 and negative odds ratio 0.0196. Conclusions: PRIDE scale was concordant with the diagnosis of primary immunodeficiency in the majority of patients with a previous confirmed diagnosis. The characteristics of diagnostic accuracy provide reliability to this instrument in the scrutiny of patients with probable immunodeficiency.
- Subjects
DISEASE prevalence; MORTALITY risk factors; IMMUNODEFICIENCY; SEVERITY of illness index; CROSS-sectional method; DIAGNOSIS
- Publication
Revista Alergia de Mexico, 2012, Vol 59, Issue 4, p192
- ISSN
0002-5151
- Publication type
Article