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- Title
Daratumumab for Refractory IgD Multiple Myeloma with Lung Cancer and Persistent Thrombocytopenia: a Case Report.
- Authors
Zhihui Wang; Hong Deng; Liang Zhang; Yaxing Dai; Xianglong Li; Xiaojing Lin; Jin Wei; Xingli Zou
- Abstract
Background: Immunoglobulin D multiple myeloma (IgD-MM) is a rare but aggressive disease. The safety and effectiveness of anti-CD38 monoclonal antibody (daratumumab) have not been known in either IgD-MM or MM complicated with secondary neoplasm. Methods: A fragile IgD-MM patient had an aggressively relapsed disease concurrent with lung cancer and severe thrombocytopenia, which led to a dilemma for management. After a failure of ixazomib-based chemotherapy, a salvage therapy with daratumumab unexpectedly induced complete remission and platelet recovery, and the patient successfully proceeded to lung cancer surgery. Conclusions: Our case indicates daratumumab is both safe and effective for refractory IgD-MM with severe complications.
- Subjects
DARATUMUMAB; MULTIPLE myeloma; LUNG cancer; CD38 antigen; MONOCLONAL antibodies; PLASMA cell diseases
- Publication
Clinical Laboratory, 2021, Vol 67, Issue 11, p2589
- ISSN
1433-6510
- Publication type
Article
- DOI
10.7754/Clin.Lab.2021.210405