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- Title
ANTI-INFLAMMATORY ACTIVITY OF INDANYLTETRAZOLE DERIVATIVES.
- Authors
Bepary, Sukumar; Das, Biplab K.; Bachar, Sitesh C.; Kundu, Joydev K.; Rouf, Abu Shara Shamsur; Datta, Bidyut K.
- Abstract
A number of indanyl tetrazolederivatives namely 5-(6′-chloroindan-1′-yl)tetrazole (CIT), 5-(6′-bromoindan- 1′-yl)tetrazole (BIT), 5-(6′-chloroindan-1′-yl)methyltetrazole (CIMT), 5-(6′-bromoindan-1′-yl)methyltetrazole (BIMT) were evaluated for the anti-inflammatory activity in carragennan induced rat paw edema in Swiss albino Wister rats for 24-hour period at the dose of 100 mg/kg of body weight by intraperitoneal route where phenylbutazone (PBZ) was used as the standard. All of these compounds exhibited inhibition on rat paw edema with peak actions observed following 3 hours after administration. Moreover, compounds CIMT and BIMT were further evaluated at dose of 50 mg/kg of body weight. Among the compounds, CIMT showed higher activity than others and was very close to standard phenylbutazone.
- Subjects
ANTI-inflammatory agents; RAT anatomy; DIRECTIONAL derivatives; CARBENICILLIN; TETRAZOLES; PHENYLBUTAZONE; AZOLES
- Publication
Pakistan Journal of Pharmaceutical Sciences, 2008, Vol 21, Issue 3, p295
- ISSN
1011-601X
- Publication type
Article