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- Title
Sunlight-Driven Decarboxylative Alkynylation of α-Keto Acids with Bromoacetylenes by Hypervalent Iodine Reagent Catalysis: A Facile Approach to Ynones.
- Authors
Tan, Hui; Li, Hongji; Ji, Wangqin; Wang, Lei
- Abstract
A novel and practical decarboxylative alkynylation of α-keto acids with bromoacetylenes is catalyzed by hypervalent iodine(III) reagents when irradiation by sunlight at room temperature. The product ynones are generated in good yields. Experiments show that results obtained with blue light ( λ=450-455 nm) are comparable to those obtained when using sunlight. Mechanistic studies demonstrate that the sunlight-driven decarboxylation undergoes a radical process.
- Subjects
DECARBOXYLATION; KETONIC acids; HYPERVALENCE (Theoretical chemistry); CHEMICAL reagents; ALKYNE synthesis; IRRADIATION
- Publication
Angewandte Chemie International Edition, 2015, Vol 54, Issue 29, p8374
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201503479