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- Title
β-Functionalization of Carboxylic Anhydrides with β-Alkyl Substituents through Carbene Organocatalysis.
- Authors
Jin, Zhichao; Chen, Shaojin; Wang, Yuhuang; Zheng, Pengcheng; Yang, Song; Chi, Yonggui Robin
- Abstract
The first NHC-catalyzed functionalization of carboxylic anhydrides is described. In this reaction, the β carbon behaves as a nucleophilic carbon and undergoes asymmetric reactions with electrophiles. Anhydrides with challenging β-alkyl substituents work effectively.
- Subjects
ANHYDRIDES; ORGANOCATALYSIS; ELECTROPHILES; NUCLEOPHILIC reactions; CHEMICAL reactions
- Publication
Angewandte Chemie International Edition, 2014, Vol 53, Issue 49, p13506
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201408604