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- Title
Visualization and Isolation of Langerhans Islets by a Fluorescent Probe PiY.
- Authors
Kang, Nam‐Young; Lee, Sung‐Chan; Park, Sung‐Jin; Ha, Hyung‐Ho; Yun, Seong‐Wook; Kostromina, Elena; Gustavsson, Natalia; Ali, Yusuf; Chandran, Yogeswari; Chun, Hang‐Suk; Bae, MyungAe; Ahn, Jin Hee; Han, Weiping; Radda, George K.; Chang, Young‐Tae
- Abstract
Lighting up the pancreas: A pancreatic beta cell selective probe PiY (red, see picture) was developed which stains Langerhans islets in live animals without toxicity or side effects. Through tail‐vein injection, PiY allowed for a comparison of the islets between healthy and diabetic mice. PiY also facilitated the isolation of healthy Langerhans islets by using a fluorescence‐guided surgical procedure.
- Subjects
PANCREATIC beta cells; ISLANDS of Langerhans; STAINS &; staining (Microscopy); MICROSCOPICAL technique; FLUORESCENCE microscopy; FLUORESCENCE yield
- Publication
Angewandte Chemie International Edition, 2013, Vol 52, Issue 33, p8557
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201302149