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- Title
Self -Adjuvanting Synthetic Antitumor Vaccines from MUC1 Glycopeptides Conjugated to T -Cell Epitopes from Tetanus Toxoid.
- Authors
Cai, Hui; Chen, Mei‐Sha; Sun, Zhan‐Yi; Zhao, Yu‐Fen; Kunz, Horst; Li, Yan‐Mei
- Abstract
The T‐helper epitope peptide P30 (green in the scheme) from tetanus toxoid was used as the immunostimulant in MUC1 glycopeptide antitumor vaccines and apparently also acts as a built‐in adjuvant. P30‐conjugated glycopeptide vaccines containing three glycans in the immunodominant motifs PDTRP and GSTAP induced much stronger immune responses and complement dependent cytotoxicity mediated killing of tumor cells when applied in plain PBS solution without complete Freund's adjuvant.
- Subjects
IMMUNOTHERAPY; SYNTHETIC vaccines; CANCER cells; VACCINES; CANCER immunology
- Publication
Angewandte Chemie International Edition, 2013, Vol 52, Issue 23, p6106
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201300390