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- Title
Anterior Retinal Cryotherapy and Intravitreal Injection of Bevacizumab in the Treatment of Nonclearing Vitreous Hemorrhage in Proliferative Diabetic Retinopathy.
- Authors
Hsieh, Min-Chin; Yeh, Po-Ting; Yang, Chung-May; Yang, Chang-Hao
- Abstract
Purpose: To evaluate the efficacy of intravitreal bevacizumab (IVB) injection combined with anterior retinal cryotherapy (ARC) in the treatment of proliferate diabetic retinopathy (PDR) with vitreous hemorrhage (VH). Methods: A retrospective case controlled study was performed on 67 cases (67 patients) with PDR and persistent VH obscuring the fundus detail for ≧3 weeks. The follow-up period was ≧6 months. Cases with extensive vitreo-retinal adhesion by ultrasonography were excluded. In the study group, transconjunctival ARC (a total of 12 spots) followed by IVB 1.25 mg was performed in the same setting; in the control group, only IVB was given. Panretinal photocoagulation was performed when possible. Repeated IVB was performed in both groups if VH persisted for >4 weeks following the initial treatment. Vitrectomy was performed if VH showed no improvement for 12 to 16 weeks. The vitreous clear-up time (VCUT) in the posterior pole and the rate of vitrectomy were compared between the 2 groups. Results: In the study group ( n=35), second treatment was required in 7 out of 35 patients (20.0%). Vitrectomy was performed in 5 (14.3%) patients. In the control group ( n=32), 8 out of 32 eyes (25.0%) underwent second injection. Four eyes (12.5%) had vitrectomy within the follow-up time. VCUT in the study and the control group was 6.9±8.7 weeks and 13.0±9.3 weeks respectively ( P=0.003). Conclusion: Combined treatment of ARC and IVB is associated with more rapid clearing of VH in eyes with PDR compared with IVB alone.
- Subjects
HEALTH outcome assessment; OPHTHALMOLOGICAL therapeutics; OPHTHALMIC drugs; COLD therapy; TREATMENT of eye diseases; RETINAL diseases; DIABETIC retinopathy treatment; HEMORRHAGE treatment
- Publication
Journal of Ocular Pharmacology & Therapeutics, 2014, Vol 30, Issue 4, p353
- ISSN
1080-7683
- Publication type
Article
- DOI
10.1089/jop.2013.0104