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- Title
Can Intravitreal Ranibizumab Alter Retrobulbar Circulation in Eyes with Age-Related Macular Degeneration?
- Authors
Yuksel, Kemal; Altinkaynak, Hasan; Kina, Adnan; Kara, Necip; Yazici, Ahmet Taylan; Demirok, Ahmet
- Abstract
Purpose: To determine the effect of a single intravitreal ranibizumab injection on retrobulbar circulation in cases with neovascular age-related macular degeneration (AMD). Methods: In this prospective and interventional study, 32 patients with neovascular AMD were enrolled. A single intravitreal ranibizumab dose was in only 1 eye per patient. Peak systolic velocity, end-diastolic velocity, resistive index and pulsatility index values in the common carotid artery, ophthalmic artery, central retinal artery, nasal posterior ciliary artery, and temporal posterior ciliary artery in both injected and uninjected healthy fellow eyes were measured using color Doppler ultrasonography at baseline and 1 week and 1 month after the injection of ranibizumab. Results: All measurements revealed no statistically significant difference among baseline, first week, and first month after injection measurements for all parameters measured in all arteries in both the injected and uninjected healthy fellow eyes. Conclusion: A single intravitreal injection of ranibizumab does not significantly affect on retrobulbar circulation of either the injected or the uninjected healthy fellow eyes with neovascular AMD.
- Subjects
HEALTH outcome assessment; RETINAL degeneration; DRUG efficacy; VASCULAR endothelial growth factor antagonists
- Publication
Journal of Ocular Pharmacology & Therapeutics, 2013, Vol 29, Issue 8, p723
- ISSN
1080-7683
- Publication type
Article
- DOI
10.1089/jop.2013.0051