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- Title
Frequency and imaging correlates of neuropsychiatric symptoms in Progressive Supranuclear Palsy.
- Authors
Cuoco, Sofia; Ponticorvo, Sara; Abate, Filomena; Tepedino, Maria Francesca; Erro, Roberto; Manara, Renzo; Di Salle, Gianfranco; Di Salle, Francesco; Pellecchia, Maria Teresa; Esposito, Fabrizio; Barone, Paolo; Picillo, Marina
- Abstract
Neuropsychiatric symptoms are intrinsic to Progressive Supranuclear Palsy (PSP) and a spoonful of studies investigated their imaging correlates. Describe (I) the frequency and severity of neuropsychiatric symptoms in PSP and (II) their structural imaging correlates. Twenty-six PSP patients underwent Neuropsychiatric Inventory (NPI) and brain 3D T1-weighted MRI. Spearman's rho with Bonferroni correction was used to investigate correlations between NPI scores and volumes of gray matter regions. More than 80% of patients presented at least one behavioral symptom of any severity. The most frequent and severe were depression/dysphoria, apathy, and irritability/lability. Significant relationships were found between the severity of irritability and right pars opercularis volume (p < 0.001) as well as between the frequency of agitation/aggression and left lateral occipital volume (p < 0.001). Depression, apathy, and irritability are the most common neuropsychiatric symptoms in PSP. Moreover, we found a relationship between specific positive symptoms as irritability and agitation/aggression and greater volume of the right pars opercularis cortex and lower volume of the left occipital cortex, respectively, which deserve further investigations.
- Subjects
PROGRESSIVE supranuclear palsy; APATHY; SYMPTOMS; GRAY matter (Nerve tissue); BONFERRONI correction
- Publication
Journal of Neural Transmission, 2023, Vol 130, Issue 10, p1259
- ISSN
0300-9564
- Publication type
Article
- DOI
10.1007/s00702-023-02676-9