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- Title
Myoepithelial carcinoma of salivary glands: a clinical analysis of 13 cases.
- Authors
Lu Ruo-Huang; Tang Zhan-Gui; Su Tong; Quan Hong-Zhi; Zhu Wen-Yuan; Gan Ping-Ping
- Abstract
PURPOSE: This study retrospectively analyzed the clinical data of 13 patients with myoepithelial carcinoma of salivary glands for improving the accuracy of diagnosis and treatment outcome. METHODS: Thirteen cases with myoepithelial carcinoma of the salivary glands in Xiangya Hospital from January 1992 to September 2010 were reviewed, including the clinical biological behavior, diagnosis, treatment and prognosis. RESULTS: Thirteen patients included 6 men and 7 women, aged from 14 to 71 years (median 40 years). The tumor occurred predominantly in the parotid gland(53.8%). Among the 13 cases, 7 were clinically misdiagnosed as benign tumors and 2 were misdiagnosed pathologically. All cases underwent operation. Two cases received surgery plus adjuvant chemotherapy; five cases underwent surgery plus adjuvant radiotherapy. 4(30.8%) had cervical lymph node metastasis and 2 cases(15.4%) developed distant metastasis. Follow--up time ranged from 3 months to 6 years. Six cases died of local recurrence or distal metastasis. CONCLUSIONS: Myoepithelial carcinoma of the salivary glands is a rare tumor. The diagnosis is depended on histology and immunohistochemistry. The tumor has a high rate of distant metastasis and high rate of lymph node metastasis in T3 to T4 cases. Radical surgery is the treatment of choice. Elective neck dissection should be considered in T3 to T4 cNO cases. The effect of chemotherapy and radiotherapy needs to be investigated. Supported by National Natural Science Foundation of China(30872895) and Key Project of Hunan Provincial Commission of Science and Technology(2008FJ2011).
- Subjects
SALIVARY gland cancer; DIAGNOSTIC errors; PROGNOSIS; PAROTID gland tumors; DRUG therapy; RADIOTHERAPY; LYMPH nodes
- Publication
Shanghai Journal of Stomatology, 2011, Vol 20, Issue 6, p615
- ISSN
1006-7248
- Publication type
Article