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- Title
CC Chemokine Receptor 4 Expression on Peripheral Blood CD4[sup +] T Cells Reflects Disease Activity of Atopic Dermatitis.
- Authors
Wakugawa, Motoshi; Nakamura, Koichiro; Kakinuma, Takashi; Onai, Nobuyuki; Matsushima, Kouji; Tamaki, Kunihiko
- Abstract
Recent studies indicate that Th1 and Th2 cells differ in their chemokine receptor expression and their responsiveness to various chemokines. Therefore, selective Th2 cell recruitment in Th2-predominant inflammatory diseases such as atopic dermatitis may be under the influence of some chemokines. It is reported that CC chemokine receptor (CCR) 4 is selectively expressed on Th2 cells whereas CXC chemokine receptor (CXCR) 3 is selectively expressed on Th1 cells. In this study we examined CCR4 and CXCR3 expression on peripheral blood CD4[sup +] and CD8[sup +] T cells obtained from adult atopic dermatitis subjects, and compared the results with those from patients with psoriasis vulgaris and healthy controls. CCR4 was preferentially expressed on CD4[sup +] T cells from atopic dermatitis subjects and CXCR3 was preferentially expressed on CD4[sup +] T cells from psoriasis vulgaris subjects. This CCR4 expression was prominent especially in severe atopic dermatitis subjects. CCR4 expression on CD4[sup +] T cells in severe atopic dermatitis subjects decreased on improvement of disease activity. CD25 was preferentially expressed on CCR4[sup +]CD4[sup +] T cells but not on CXCR3[sup +]CD4[sup +] T cells in atopic dermatitis subjects. Cutaneous lymphocyte-associated antigen was also preferentially expressed on CCR4[sup +]CD4[sup +] T cells but not on CXCR3[sup +]CD4[sup +] T cells in atopic dermatitis subjects. CD4[sup +] T cells in atopic dermatitis skin lesions were predominantly CCR4[sup +] cells. Taken together, this study strongly indicates that CCR4[sup +]CD4[sup +] T cells reflect disease activity and suggests that CCR4 expression is important for T cell infiltration into atopic dermatitis lesions. Thus, CCR4 may be a possible target for therapy of atopic dermatitis in the future.
- Subjects
CHEMOKINES; T cells; ATOPIC dermatitis
- Publication
Journal of Investigative Dermatology, 2001, Vol 117, Issue 2, p188
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1046/j.0022-202x.2001.01430.x