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- Title
First report of a null allele on a GYPB*s background: GYPB*s(37 + 4_8delAGTGA).
- Authors
Thonier, Vincent Louis; Floch, Aline; Babinet, Jérome; Pirenne, France; Vege, Sunitha; Tournamille, Christophe; Westhoff, Connie M.; Peyrard, Thierry
- Abstract
Two prevalent ~100-kb GYPB deletions causative of the GPB-deficient blood group MNS phenotype S-s-U- in black Africans. The antigens of the MNS blood group system (ISBT002) are carried by glycophorin A and glycophorin B, encoded by I GYPA i and I GYPB i genes, respectively.1,2 A third gene, I GYPE i , located at the same 4q31.21 locus as I GYPA i and I GYPB i , does not express known antigens but participates in gene rearrangements.3 With 50 recognized antigens and over 50 alleles reported, including many hybrids, the MNS system is the second-most polymorphic and complex after RH. Multiple GYPB gene deletions associated with the U- phenotype in those of African ancestry.
- Publication
Transfusion, 2022, Vol 62, Issue 5, pE24
- ISSN
0041-1132
- Publication type
Article
- DOI
10.1111/trf.16874