We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
HLA-DRB1*09:01 allele is associated with anti-E immunization in a Chinese population.
- Authors
Tian, Li; Hou, Li; Wang, Lixin; Xu, Hong; Xiao, Jie; Ying, Binwu
- Abstract
<bold>Background: </bold>Anti-E is the most common and important RBC alloantibody in the Chinese population. Several studies have demonstrated that the production of specific RBC alloantibodies is associated with HLA-DRB1 polymorphisms. Considering that the Chinese population has its own unique characteristics of HLA-DRB1 polymorphisms, we investigate whether specific HLA-DRB1 alleles are associated with E immunization in a Chinese population.<bold>Study Design and Methods: </bold>The frequencies of HLA-DRB1 phenotypes were compared among 78 patients possessing anti-E and 192 healthy blood donors. HLA-DRB1 genotyping was carried out using sequence-based typing method. The TEPITOPEpan software was used to predict E antigen-derived anchor peptides binding to HLA-DRB1 molecules.<bold>Results: </bold>The frequency of HLA-DRB1*09:01 phenotype was significantly higher in the patients with anti-E than in healthy controls: 76.9% versus 27.6% (odds ratio, 8.7; 95% confidence interval, 4.7-16.2; corrected p value < 0.0034). One E antigen-derived anchor peptide (217WMFWPSVNS225) was predicted to bind three HLA-DRB1 molecules (HLA-DRB1*04:05, *04:17, and *13:02); however, no anchor peptide was predicted to bind HLA-DRB1*09:01.<bold>Conclusion: </bold>This study indicated that HLA-DRB1*09:01 phenotype was significantly more prevalent in E-immunized patients than the control group. It suggested that HLA-DRB1*09:01 molecule might represent a susceptibility phenotype enhancing formation of anti-E alloantibody. Further study would be necessary to identify the anchor peptide responsible for E alloimmunization by stimulation of specific T cells by peptide originating from E antigen.
- Subjects
CHINA; ERYTHROCYTES; BLOOD transfusion; BLOOD groups; HLA histocompatibility antigens; HEMOLYTIC anemia; ALLELES; CONFIDENCE intervals; GENETIC polymorphisms; IMMUNOGLOBULINS; HLA-B27 antigen; DESCRIPTIVE statistics; SEQUENCE analysis; ODDS ratio; GENOTYPES
- Publication
Transfusion, 2018, Vol 58, Issue 6, p1536
- ISSN
0041-1132
- Publication type
journal article
- DOI
10.1111/trf.14568