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- Title
RNA modifications in cancer.
- Authors
Tang, Qiling; Li, Lvyuan; Wang, Yumin; Wu, Pan; Hou, Xiangchan; Ouyang, Jiawei; Fan, Chunmei; Li, Zheng; Wang, Fuyan; Guo, Can; Zhou, Ming; Liao, Qianjin; Wang, Hui; Xiang, Bo; Jiang, Weihong; Li, Guiyuan; Zeng, Zhaoyang; Xiong, Wei
- Abstract
Currently, more than 170 modifications have been identified on RNA. Among these RNA modifications, various methylations account for two-thirds of total cases and exist on almost all RNAs. Roles of RNA modifications in cancer are garnering increasing interest. The research on m6A RNA methylation in cancer is in full swing at present. However, there are still many other popular RNA modifications involved in the regulation of gene expression post-transcriptionally besides m6A RNA methylation. In this review, we focus on several important RNA modifications including m1A, m5C, m7G, 2′-O-Me, Ψ and A-to-I editing in cancer, which will provide a new perspective on tumourigenesis by peeking into the complex regulatory network of epigenetic RNA modifications, transcript processing, and protein translation.
- Publication
British Journal of Cancer, 2023, Vol 129, Issue 2, p204
- ISSN
0007-0920
- Publication type
Article
- DOI
10.1038/s41416-023-02275-1